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Colorectal Cancer

Overview

Colorectal cancer, also known as colon cancer or rectal cancer, develops in the colon (large intestine) or rectum. It usually starts as polyps, which are small growths that can become cancerous over time. This cancer is one of the most common types worldwide but is highly treatable if detected early.

Causes and Risk Factors

Several factors increase the risk of colorectal cancer, including:

  • Age – Most cases occur in people over 50

  • Family history – A genetic predisposition may increase the risk

  • Diet high in red and processed meats – Increases risk of colon cancer

  • Low-fiber diet – A diet lacking fruits, vegetables, and whole grains may contribute

  • Obesity and sedentary lifestyle – Linked to a higher risk of colorectal cancer

  • Smoking and excessive alcohol consumption

  • Inflammatory bowel disease (IBD) – Conditions like Crohn’s disease and ulcerative colitis increase risk

  • Diabetes – People with type 2 diabetes are at a higher risk

Symptoms

Colorectal cancer symptoms may not appear until the disease has progressed. Common signs include:

  • Changes in bowel habits (diarrhea, constipation, or narrow stools)

  • Blood in the stool (bright red or dark-colored)

  • Unexplained weight loss

  • Abdominal pain, cramps, or bloating

  • Feeling of incomplete bowel emptying

  • Fatigue and weakness

If you experience these symptoms persistently, consult a doctor for evaluation.

Diagnosis

To diagnose colorectal cancer, doctors may use:

  • Colonoscopy – A flexible tube with a camera examines the colon and rectum

  • Biopsy – A tissue sample is taken for laboratory testing

  • CT scan or MRI – Helps determine the extent of cancer spread

  • Fecal occult blood test (FOBT) – Detects hidden blood in stool

  • Blood tests – Measures tumor markers like CEA (carcinoembryonic antigen)

Treatment Options

Treatment depends on the stage and location of the cancer. Options include:

1. Surgery

  • Polypectomy – Removal of small polyps during a colonoscopy (for early-stage cancer)

  • Colectomy or proctectomy – Partial or complete removal of the colon or rectum

  • Lymph node removal – Helps prevent cancer spread

2. Chemotherapy

  • Uses drugs to destroy cancer cells, often combined with surgery or radiation

  • Common drugs include 5-FU (fluorouracil), oxaliplatin, and capecitabine

3. Radiation Therapy

  • High-energy rays target and destroy cancer cells, especially for rectal cancer

4. Targeted Therapy & Immunotherapy

  • Monoclonal antibodies and immune checkpoint inhibitors help fight cancer in advanced cases

5. Palliative Care

  • For advanced-stage cancer, treatments focus on relieving symptoms and improving quality of life

Prognosis and Prevention

Early detection significantly improves survival rates for colorectal cancer. Regular screenings and a healthy lifestyle can reduce the risk.

Prevention Tips:

  • Get regular colonoscopies starting at age 45 or earlier if you have a family history

  • Eat a fiber-rich diet with plenty of fruits, vegetables, and whole grains

  • Limit red and processed meat consumption

  • Exercise regularly and maintain a healthy weight

  • Quit smoking and reduce alcohol intake

  • Manage inflammatory bowel disease (IBD) and diabetes properly

Colorectal cancer is one of the most preventable cancers. Early screening and lifestyle changes can greatly reduce your risk. If you notice persistent symptoms, consult a doctor for evaluation.

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